The N-terminal Fragment from Caspase-cleaved Serine/Arginine Protein-specific Kinase2 (SRPK2) Translocates into the Nucleus and Promotes Apoptosis
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چکیده
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Sequence confirmation and characterization of the mouse Ssxa gene: Ssxa protein is cleaved and the N-terminal cleaved fragment translocates into the nucleus.
This is the first demonstration of a stop codon in the sequence of mouse Ssxa and characterization of the biological behavior of Ssxa protein. Cancer testis antigen (CTA) is known as a target of immunotherapy against cancer, and Ssxa is one of the CTAs. Although a CTA would be useful to establish a mouse cancer vaccine model using endogenous antigen, the stop codon was not identified in the seq...
متن کاملThe familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV, which encodes a 781-amino acid protein denoted pyrin. We have previously shown that pyrin regulates caspase-1 activation and IL-1beta production through interaction of its N-terminal PYD motif with the ASC adapter protein, and also modulates IL-1beta production by interaction of its C-terminal B30.2 d...
متن کاملThe familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF- B through its N-terminal fragment
http://bloodjournal.hematologylibrary.org/content/112/5/1794.full.html Updated information and services can be found at: (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found onli...
متن کاملRanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis.
Acetylcholinesterase (AChE) expression may be induced during apoptosis in various cell types. Here, we used the C-terminal of AChE to screen the human fetal brain library and found that it interacted with Ran-binding protein in the microtubule-organizing center (RanBPM). This interaction was further confirmed by coimmunoprecipitation analysis. In HEK293T cells, RanBPM and AChE were heterogeneou...
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این تحقیق به بررسی استراتژیهای بکاررفته توسط مترجمین مختلف در ترجمه واژه های فرهنگی خاص در ترجمه فارسی به انگلیسی قانون مدنی و قانون اساسی جمهوری اسلامی ایران میپردازد.این تحقیق بر اساس نظریه پیتر نیومارک صرت گرفته است. در این تحفیق واژه های فرهنگی خاص اقتباس شده و پس از مقایسه با متن مبدا به بررسی انها پرداخته می شود.در قسمت ضمائم تحقیق واژه نامه ای برای اشنایی خوانندگان با لغات و اصطلاحات حقو...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.193441